Incorporation of ubiquinone in supported lipid bilayers on ITO.
Identifieur interne : 000611 ( Main/Exploration ); précédent : 000610; suivant : 000612Incorporation of ubiquinone in supported lipid bilayers on ITO.
Auteurs : RBID : pubmed:23725098English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : 1,2-Dipalmitoylphosphatidylcholine, Lipid Bilayers, Tin Compounds, Ubiquinone.
- Electrochemical Techniques, Microscopy, Atomic Force.
Abstract
Ubiquinone (UQ) is one of the main electron and proton shuttle molecules in biological systems, and dipalmitoylphosphatidylcholine (DPPC) is one of the most used model lipids. Supported planar bilayers (SPBs) are extensively accepted as biological model membranes. In this study, SPBs have been deposited on ITO, which is a semiconductor with good electrical and optical features. Specifically, topographic atomic force microscopy (AFM) images and force curves have been performed on SPBs with several DPPC:UQ ratios to study the location and the interaction of UQ in the SPB. Additionally, cyclic voltammetry has been used to understand the electrochemical behavior of DPPC:UQ SPBs. Obtained results show that, in our case, UQ is placed in two main different positions in SPBs. First, between the DPPC hydrophobic chains, fact that originates a decrease in the breakthrough force of the bilayer, and the second between the two leaflets that form the SPBs. This second position occurs when increasing the UQ content, fact that eventually forms UQ aggregates at high concentrations. The formation of aggregates produces an expansion of the SPB average height and a bimodal distribution of the breakthrough force. The voltammetric response of UQ depends on its position on the bilayer.
DOI: 10.1021/jp4004517
PubMed: 23725098
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Incorporation of ubiquinone in supported lipid bilayers on ITO.</title><author><name sortKey="Hoyo, Javier" uniqKey="Hoyo J">Javier Hoyo</name><affiliation wicri:level="1"><nlm:affiliation>Universitat Politècnica de Catalunya, Dpt. Enginyeria Química, 08222 Terrassa (Barcelona), Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Politècnica de Catalunya, Dpt. Enginyeria Química, 08222 Terrassa (Barcelona)</wicri:regionArea></affiliation></author><author><name sortKey="Guaus, Ester" uniqKey="Guaus E">Ester Guaus</name></author><author><name sortKey="Oncins, Gerard" uniqKey="Oncins G">Gerard Oncins</name></author><author><name sortKey="Torrent Burgues, Juan" uniqKey="Torrent Burgues J">Juan Torrent-Burgués</name></author><author><name sortKey="Sanz, Fausto" uniqKey="Sanz F">Fausto Sanz</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.1021/jp4004517</idno><idno type="RBID">pubmed:23725098</idno><idno type="pmid">23725098</idno><idno type="wicri:Area/Main/Corpus">000601</idno><idno type="wicri:Area/Main/Curation">000601</idno><idno type="wicri:Area/Main/Exploration">000611</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1,2-Dipalmitoylphosphatidylcholine (chemistry)</term><term>Electrochemical Techniques</term><term>Lipid Bilayers (chemistry)</term><term>Microscopy, Atomic Force</term><term>Tin Compounds (chemistry)</term><term>Ubiquinone (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>1,2-Dipalmitoylphosphatidylcholine</term><term>Lipid Bilayers</term><term>Tin Compounds</term><term>Ubiquinone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electrochemical Techniques</term><term>Microscopy, Atomic Force</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ubiquinone (UQ) is one of the main electron and proton shuttle molecules in biological systems, and dipalmitoylphosphatidylcholine (DPPC) is one of the most used model lipids. Supported planar bilayers (SPBs) are extensively accepted as biological model membranes. In this study, SPBs have been deposited on ITO, which is a semiconductor with good electrical and optical features. Specifically, topographic atomic force microscopy (AFM) images and force curves have been performed on SPBs with several DPPC:UQ ratios to study the location and the interaction of UQ in the SPB. Additionally, cyclic voltammetry has been used to understand the electrochemical behavior of DPPC:UQ SPBs. Obtained results show that, in our case, UQ is placed in two main different positions in SPBs. First, between the DPPC hydrophobic chains, fact that originates a decrease in the breakthrough force of the bilayer, and the second between the two leaflets that form the SPBs. This second position occurs when increasing the UQ content, fact that eventually forms UQ aggregates at high concentrations. The formation of aggregates produces an expansion of the SPB average height and a bimodal distribution of the breakthrough force. The voltammetric response of UQ depends on its position on the bilayer.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23725098</PMID><DateCreated><Year>2013</Year><Month>06</Month><Day>27</Day></DateCreated><DateCompleted><Year>2014</Year><Month>01</Month><Day>28</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5207</ISSN><JournalIssue CitedMedium="Internet"><Volume>117</Volume><Issue>25</Issue><PubDate><Year>2013</Year><Month>Jun</Month><Day>27</Day></PubDate></JournalIssue><Title>The journal of physical chemistry. B</Title><ISOAbbreviation>J Phys Chem B</ISOAbbreviation></Journal><ArticleTitle>Incorporation of ubiquinone in supported lipid bilayers on ITO.</ArticleTitle><Pagination><MedlinePgn>7498-506</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/jp4004517</ELocationID><Abstract><AbstractText>Ubiquinone (UQ) is one of the main electron and proton shuttle molecules in biological systems, and dipalmitoylphosphatidylcholine (DPPC) is one of the most used model lipids. Supported planar bilayers (SPBs) are extensively accepted as biological model membranes. In this study, SPBs have been deposited on ITO, which is a semiconductor with good electrical and optical features. Specifically, topographic atomic force microscopy (AFM) images and force curves have been performed on SPBs with several DPPC:UQ ratios to study the location and the interaction of UQ in the SPB. Additionally, cyclic voltammetry has been used to understand the electrochemical behavior of DPPC:UQ SPBs. Obtained results show that, in our case, UQ is placed in two main different positions in SPBs. First, between the DPPC hydrophobic chains, fact that originates a decrease in the breakthrough force of the bilayer, and the second between the two leaflets that form the SPBs. This second position occurs when increasing the UQ content, fact that eventually forms UQ aggregates at high concentrations. The formation of aggregates produces an expansion of the SPB average height and a bimodal distribution of the breakthrough force. The voltammetric response of UQ depends on its position on the bilayer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hoyo</LastName><ForeName>Javier</ForeName><Initials>J</Initials><Affiliation>Universitat Politècnica de Catalunya, Dpt. Enginyeria Química, 08222 Terrassa (Barcelona), Spain.</Affiliation></Author><Author ValidYN="Y"><LastName>Guaus</LastName><ForeName>Ester</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Oncins</LastName><ForeName>Gerard</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Torrent-Burgués</LastName><ForeName>Juan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Sanz</LastName><ForeName>Fausto</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>06</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Phys Chem B</MedlineTA><NlmUniqueID>101157530</NlmUniqueID><ISSNLinking>1520-5207</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Lipid Bilayers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Tin Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>1339-63-5</RegistryNumber><NameOfSubstance>Ubiquinone</NameOfSubstance></Chemical><Chemical><RegistryNumber>2644-64-6</RegistryNumber><NameOfSubstance>1,2-Dipalmitoylphosphatidylcholine</NameOfSubstance></Chemical><Chemical><RegistryNumber>71243-84-0</RegistryNumber><NameOfSubstance>indium tin oxide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">1,2-Dipalmitoylphosphatidylcholine</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Electrochemical Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lipid Bilayers</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Microscopy, Atomic Force</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tin Compounds</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Ubiquinone</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>6</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>6</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>6</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1021/jp4004517</ArticleId><ArticleId IdType="pubmed">23725098</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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